Author: Marian Chandler

New!  Head Injury Guideline Algorithm Video

By

Dear PREDICT members,

We are pleased to let you know that a new video has been developed to accompany the PREDICT Australian and New Zealand Guideline for Mild to Moderate Head injuries in Children Algorithm, which outlines the key Imaging and Observation Decision-Making recommendations and how to use the algorithm in your clinical decision -making. It is now available to view on the PREDICT website at: https://www.predict.org.au/head-injury-guideline/dftb-education-modules/

This is in addition to the education modules developed by DFTB.

 

 

 

 

WRAP IT UP FOR 2021

By

2021 has been another unique and challenging year for everyone during the COVID 19 pandemic. Despite this, PREDICT research has continued to progress and there has still been significant work accomplished across our network. This year also marks the second year of our 2020-2024 NHMRC Centre for Research Excellence (CRE) collaboration which will continue to support a program of excellent research in the years to come.

Please join us in reflecting on these and other outstanding achievements:

  • PREDICT now has 179 members – in the past year we welcomed 20 new members. This year a survey of members was undertaken to gain an understanding of how members perceive network activities deemed critical for network success and to determine how we can best meet the needs of PREDICT members in the future. Findings of the survey will inform future work next year.
  • PREDICT has continued working actively with consumers in our research. Our mental health consumer group recruited for “The Kids are not Okay” program of research has been actively involved in the development and fine tuning of the Mental Health Delphi project, the PEACHY O and M studies, and the Prospective Observational study. The Perth Children’s Hospital ED consumers have been involved in our PROMPT Bolus and our Research Priorities studies. We are also about to commence a “Codesign” project that involves parents, youths and consumers working in partnership to develop discharge materials for children with mild head injury/concussion. Lots of valuable insight has been gained to date.
  • 58 hospitals across Australia and New Zealand have been actively involved in PREDICT research!
  • The Acute Head Injury Guidelines are completed and are available on our website! Supplementary materials, including a video on use of the head injury algorithm, and other education modules, are in development and will be available soon.
  • A mRNA Vaccine Chest Pain guideline has been developed in collaboration with ATAGI (Australian Technical Advisory Group on Immunisation), IMAC (Immunisation Advisory Centre NZ) and CSANZ (Cardiac Society of Australia and New Zealand) to support an approach to the initial assessment and workup of children and adolescents presenting to the ED with vaccine-related symptoms. This is available on our website now.
  • Our two committed teams undertaking Cochrane reviews continue to progress work on:
    “Triage tools for detecting cervical spine injury in paediatric trauma patients”
    “Parenteral medication for the management of acute severe behavioural disturbance (ASBD) in the emergency department”
  • A number of new studies have commenced recruitment this year after significant preparatory work.  These include: The Sepsis Observational (SENTINEL) study, currently enrolling in Australia (5 sites). The PEACHY O and PEACHY M RCT studies which focus on the care of children with acute severe behavioural disturbance in the ED (7 sites).
  • The Western Australia Adaptability study and the Bronchiolitis Sustainability study are now both underway and will contribute to our knowledge of implementation in the Emergency Department setting.
  • Data analysis is complete and paper submitted for the BellPIC RCT. The PERN pneumonia and the PARIS II project data collections are complete and analysis is well underway!
  • We continue to undertake work collaboratively with the international PERN Pediatric Emergency Research Network) group on the PERN COVID 19 project, the PERC BIPED study (Dexamethasone and Adrenalin for bronchiolitis), and the PAINT study (Pain Management and Sedation in Pediatric Ileocolic Intussusception: A Global, Multicenter, Retrospective Study).
  • Other international studies include the PROMPT Bolus Study (US and Canada) and the SONIC study (Study of neck injuries in children: A prospective observational study to develop a new or validate existing international clinical decision rules for children presenting to the emergency department with suspected cervical spine injuries). Both of these studies are up and running – congratulations to the teams involved.
  • The PREDICT Executive reviewed and endorsed 8 new projects, most of which are now in various stages of development.
  • We continue to mentor 8 PhD scholars and one MD.
  • Twenty-four papers were published in various Journals including JAMA Paediatrics, Archives of Disease in Childhood, Journal of Neurology, BMC Health Services Research, Journal of Paediatrics and Child Health, Emergency Medicine Journal, BMC Paediatrics, Medical Journal Australia and others!
  • The annual PREDICT members meeting was held in October online via zoom and attended by 57 members.

Thank you to all members and collaborators for your contributions and support.

 

New PREDICT publications

By

Congratulations to the following PREDICT authors:

Babl FE, Rausa VC, Borland ML, Kochar A, Lyttle MD, Phillips N, Gilhotra Y, Dalton S, Cheek JA, Furyk J, Neutze J, Bressan S, Davis GA, Anderson V, Williams A, Oakley E, Dalziel SR, Crowe LM, Hearps SJC. Characteristics of concussion based on patient age and sex: a multicenter prospective observational study. J Neurosurg Pediatr. 2021 Oct 1:1-10. doi: 10.3171/2021.6.PEDS20953. Epub ahead of print. PMID: 34598158.

Weiss SL, Balamuth F, Long E, Thompson GC, Hayes KL, Katcoff H, Cook M, Tsemberis E, Hickey CP, Williams A, Williamson-Urquhart S, Borland ML, Dalziel SR, Gelbart B, Freedman SB, Babl FE, Huang J, Kuppermann N; Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis (PRoMPT BOLUS) Investigators of the PECARN, PERC, and PREDICT Networks. PRagMatic Pediatric Trial of Balanced vs nOrmaL Saline FlUid in Sepsis: study protocol for the PRoMPT BOLUS randomized interventional trial. Trials. 2021 Nov 6;22(1):776. doi: 10.1186/s13063-021-05717-4. PMID: 34742327; PMCID: PMC8572061.

Haskell L, Tavender EJ, O’Brien S, Wilson CL, Babl FE, Borland ML, Schembri R, Orsini F, Cotterell E, Sheridan N, Oakley E, Dalziel SR, for the Paediatric Research in Emergency Departments International Collaborative (PREDICT) network, Australasia. Process evaluation of a cluster randomised controlled trial to improve bronchiolitis management – a PREDICT mixed-methods study. BMC Health Services Research (2021) 21:1282. https://doi.org/10.1186/s12913-021-07279-2.

Useful member information on website

By

The PREDICT website at http://www.predict.org.au has a wealth of information and resources at hand for all members.  Please take the time to familiarise yourself with the website as information is constantly being added or updated.  Of course, if you can’t find the information you need, Marian or Cate can assist but please try the website first.

Some of the more commonly used links that are especially useful for all members are listed here:

Project Snapshot – PEAChY O and M

By

PEAChY-0: Pharmacological Emergency management of Agitation in Children and Young people – A randomised controlled trial of Oral medication

PEAChY-M: Pharmacological Emergency management of Agitation in Children and Young people – A randomised controlled trial of IntraMuscular medication

Trial Designs:

Randomised, controlled, open-label, multi-centre, phase III superiority effectiveness trials of: ORAL olanzapine vs ORAL diazepam and IM olanzapine vs IM droperidol.

Aim:

To determine in children and adolescents aged ≥9 years to <18 years with acute severe behavioural disturbance (ASBD) whether oral olanzapine is more effective than oral diazepam and whether IM olanzapine is more effective than IM droperidol at achieving successful sedation at 1 hour post randomisation, without the requirement of additional medication. The Sedation Assessment Tool (SAT) will be used to score sedation and agitation levels – a SAT of ≤0 will be considered “successful sedation”.

Setting & Target:

7 PREDICT paediatric ED sites in Australia.  A total of 348 participants will be recruited in each trial.

  • Royal Children’s Hospital Melbourne – HREC amendment approval for PEAChY-O obtained 26th August. Recruitment commenced 18th October, 2021. HREC approval for PEAChY-M obtained 6th September, 2021. Recruitment commenced 20th October, 2021.
  • Monash Medical Centre
  • Perth Children’s Hospital
  • Women’s and Children’s Hospital, Adelaide – RGO approval obtained 2nd November, 2021
  • Children’s Hospital at Westmead
  • Gold Coast University Hospital – RGO approval obtained 25th October, 2021
  • Queensland Children’s Hospital

PEAChY-O Status: Six participants enrolled.
PEAChY-M Status: Two participants enrolled.

Update:
  • Ongoing review of recruitment processes and documents continues at RCH.
  • Education to commence recruitment at participating sites anticipated to commence in February, 2022.

Implementation research meeting – March 2022

By

PREDICT members who have previously been involved in implementation research studies or are involved in current work, have been invited to attend a one-day online meeting ‘Implementation research in the PREDICT network – what is implementation research, what have we achieved and where are we heading?’ in March 2022.

The aims of the meeting are to:
i) provide education on the basics of implementation research
ii) provide examples of implementation research that have been undertaken in other clinical areas
iii) discuss future implementation research projects and implementation research training needs for the PREDICT network.

Spaces are limited, however, if you have not been invited and would like to attend, please contact Cate Wilson (Catherine.wilson@mcri.edu.au) .

 

PREDICT members meeting 2021

By

The annual PREDICT members meeting was held online via zoom on October 20th 2021 and attended by 57 members.  The meeting included a range of informative presentations from the project leads, members and the executive team.  A recording of the slide presentations will be available soon and posted in the secure staff area of the website for those who missed the meeting or want a recap of events.

We look forward to another exciting year of collaborative research and another online and/or face-to-face meeting in 2022!

 

 

 

 

PREDICT Resources

By

PREDICT resources:

There are a range of PREDICT resources and information on our website that we would like to make you aware of.

Please see below links to these resources below:

 

New PREDICT publications

By

Congratulations to the following PREDICT authors:

Ting A, Smith K, Wilson CL, Babl FE, Hopper SM. Pre-hospital intraosseous use in children: Indications and success rate. Emerg Med Australas. 2021 Oct 26. doi: 10.1111/1742-6723.13886. Epub ahead of print. PMID: 34704359.

Prompt Bolus & Sentinel recruitment update

By

PROMPT Bolus recruitment numbers to date:
Royal Children’s Hospital: 19
Perth Children’s Hospital: 6
Monash Children’s Hospital: 0
Canada: not enrolling yet
US: 14 sites enrolling, 297 patients enrolled to date.

SENTINEL recruitment numbers to date:
In total – 316 patients recruited.

Royal Children’s Hospital: 258
Perth Children’s Hospital: 32
Monash Children’s Hospital: 3
Women’s & Children’s Health Adelaide: 23

Start dates for both studies
Perth Children’s Hospital: 20/9/21
Monash Children’s Hospital:  28/9/21
Women’s & Children’s Health Adelaide: 11/10/21 (Sentinel) & 18/10/21 (Prompt Bolus)
Gold Coast University Hospital: starting 8/11/21