SAVE THE DATE – PREDICT MEMBERS MEETING 2021

The PREDICT members meeting will be held on Wednesday 20th October 2021 online via Zoom from 11.00am – 2.00pm (AEST).

Due to time constraints this year, presentations will be very focused and not all projects presented. Written reports on the status of all PREDICT projects and the relevant project contact, will be made available to all members. An agenda will be forwarded closer to the date.

An outlook invitation has been sent to all PREDICT members which contains the Zoom link to join the meeting.  All you need to do is to accept the invitation.

We hope you can join us on the day.

Questions?

Please contact Catherine.wilson@mcri.edu.au

 

Elyssia Bourke awarded Buchanan Prize

Huge congratulations to PREDICT PhD candidate Elyssia Bourke for being awarded the Buchanan Prize by the Australasian College for Emergency Medicine (ACEM) for top performing candidate in the 2021 Fellowship Clinical Examination (OSCE).

These awards don’t come easily and this is testament to Elyssia’s hard work and dedication and “never give up” attitude.

Well done Elyssia.

 

New PREDICT publications

Congratulations to the following authors:

Eapen N, Kochar A, Lyttle MD, Phillips N, Cheek JA, Furyk J, Neutze J, Bressan S, Williams A, Hearps S, Oakley E, Dalziel SR, Borland ML, Babl FE; Paediatric Research in Emergency Departments International Collaborative (PREDICT). Seizure- and syncope-related head injuries in children: A prospective PREDICT cohort study. Emerg Med Australas. 2021 Jun 8. doi: 10.1111/1742-6723.13812. Online ahead of print. PMID: 34105253.

Klassen T, Dalziel SR, Babl FE, Benito J, Bressan S, Chamberlain J, Chang TP, Freedman SB, Kohn-Loncarica G, Lyttle MD, Mintegi S, Mistry RD, Nigrovic LE, Oostenbrink R, Plint AC, Rino P, Roland D, Van De Mosselaer G, Kuppermann. The Pediatric Emergency Research Network: A Decade of Global Research Cooperation in Pediatric Emergency Care. Emerg Care. 2021 Jun 3. doi: 10.1097/PEC.0000000000002466. Online ahead of print.PMID: 34091572.

 

 

 

 

Getting to know you – meet Katie Reeves

Our “Getting to Know You” segment ensures PREDICT members are aware of new members, their interests and areas of expertise and where they are located.

This month we introduce Katie Reeves from QCH.  Welcome to PREDICT Katie.

“Hi everyone, I’m one of many Katies that work at the Queensland Children’s Hospital Emergency Department in sunny Queensland.  When it comes to research I am a complete novice, but I’m an enthusiastic learner and improving my research skills is something I’m really focusing on for the next few years. I have joined PREDICT to be a part of the work with the Australian and New Zealand Airway Registry, and am also currently working on a qualitative study to evaluate our ED Clinical Event Debriefing Program. I otherwise am a keen traveller, an AFL lover (Go Lions!), an avid music fan, and a doting aunty.

I’m looking forward to being a part of PREDICT and the opportunities it provides.”

Project Snapshot – Observational study of COVID-19 Infections

Observational study of COVID-19 Infections: Clinical Characteristics and Outcomes at PREDICT Sites

Aim:
Describe clinical features and outcomes of patients < 18 years who tested positive with COVID-19 and presented to hospitals across Australia in the PREDICT network.

Design:
A multicentre retrospective study involving data extraction from medical records.

Recruitment:

  • Sites – 16 hospitals in 5 Australian states
  • Cases – Total of 393 SARS-CoV-2 positive children were reported across the 16 sites between February 3 to 30th September 2020. Cases presented to hospital respiratory clinics or ED.
  • These cases generated 426 hospital presentations.

Current Status:

  • All study data has been entered, cleaned and analysed.
  • Publication has been submitted.
  • Outcomes will be reported soon.

 

New PREDICT publications

Congratulations to the following authors:

Bourke EM, Say DF, Carison A, Hill A, Craig S, Hiscock H, Babl FE, O’Donnell SM. Emergency mental health presentations in children with autism spectrum disorder and attention deficit hyperactivity disorder. J Paediatr Child Health. Advance online publication. https://doi.org/10.1111/jpc/15535.

 

 

Project Snapshot – KidsTHRIVE

Trans-nasal Humidified Rapid- Insufflation Ventilatory Exchange in Children Requiring Emergent Intubation

Aim
The aim of this study is to assess the effect of THRIVE as a method for prolonging apnoeic oxygenation during the emergency intubation of children to reduce the proportion adverse events (specifically, oxygen desaturation) and increase the proportion of first attempt success for endotracheal intubation.

Recruitment stats as @ 22/4/20

  • Study commenced 09/05/2021
  • Sample size: 960
  • Current Overall Enrolment Total: 674

Sites currently recruiting as @ 22/4/20

  • Queensland Children’s Hospital – ED & PICU
  • Children’s Hospital at Westmead – PICU
  • Gold Coast University Hospital – ED & PICU
  • Monash Children’s Hospital – ED & PICU
  • Perth Children’s Hospital – PICU
  • Royal Children’s Hospital, Melbourne – PICU & NICU
  • Townsville Hospital – ED & PICU
  • Women’s and Children’s Hospital PICU

Planned to start recruitment in 2021

  • Planned to start recruitment in 2021
  • BC Children’s Hospital Vancouver – PICU
  • University Children’s Hospital Zurich – PICU

News:
1,780 children have been screen for inclusion into the KIDS THRIVE study and to date 674 have been randomised and consented. Of the enrolled children approximately 12% have been intubated in the ED, 81% in the PICU and 7% in the NICU. This study has been approved for consent to continue (delayed consent) due to the emergent nature of intubations. In 2020 a systematic, prioritized, risk-based approach to monitoring the KIDS THRIVE project was undertaken and centralised in depth source documentation verification and monitoring of the trial has now commenced.

The Kids THRIVE Trial Steering Committee (TSC) had complex discussions in March 2020 regarding the unfolding COVID-19 health crisis and the unique nature of the coronavirus infection and disease in children and recommended the study not be paused and that sites be allowed to develop their own local plan on how to manage the recruitment of patients. In order to support sites the protocol was amended to allow for verbal consent to be obtained by the research staff.

The KIDS THRIVE study received initial seed funding from the Emergency Medicine Foundation, and additional funding from the Thrasher Research Fund and the National Health and Medical Research Council.

 

Project Snapshot – PEAChY-O

PEAChY-0: Pharmacological Emergency management of Agitation in Children and Young people – A randomised controlled trial of Oral medication

Trial Design:
Pragmatic, open-label, multi-centre, phase III superiority, randomised controlled trial (RCT).

Aim:
To determine in children and adolescents aged ≥7 years to <18 years with acute severe behavioural disturbance (ASBD) whether oral olanzapine is more effective than oral diazepam at achieving successful sedation at 30 minutes, without the requirement of additional medication or the presence of medication related adverse events. The Sedation Assessment Tool (SAT) will be used to score sedation and agitation levels – a SAT of ≤0 will be considered “successful sedation”.

Setting & Target:
7 PREDICT paediatric ED sites in Australia. A total of 348 participants will be recruited.

  • Royal Children’s Hospital Melbourne – HREC approval obtained 5th March. Recruitment to commence on 1st June, 2021
  • Monash Medical Centre
  • Perth Children’s Hospital
  • Women’s and Children’s Hospital, Adelaide
  • Children’s Hospital at Westmead
  • Gold Coast University Hospital
  • Queensland Children’s Hospital

Status:
RCH Ethics approved. RCH Ethics amendment approval pending. Local governance applications at all sites will commence shortly after approval obtained. Anticipated commencement date at lead site (RCH) June 1st, 2021.

Update: The PEAChY-M: Pharmacological Emergency management of Agitation in Children and Young people – A randomised controlled trial of intraMuscular medication trial protocol has been distributed for review by the steering committee members. It will be submitted to RCH HREC in May.

New PREDICT publications

Congratulations to the following authors:

Haskell L, Tavender EJ, Wilson CL, O’Brien S, Babl FE, Borland ML, Cotterell E, Schembri R, Orsini F, Sheridan N, Johnson DW, Oakley E, Dalziel SR; PREDICT Network. Effectiveness of Targeted Interventions on Treatment of Infants With Bronchiolitis: A Randomized Clinical Trial. JAMA Pediatr. 2021 Apr 12. doi: 10.1001/jamapediatrics.2021.0295. Epub ahead of print. PMID: 33843971.

See link to review of the paper on the DFTB website here.

 

Head Injury Guideline released

The PREDICT Australian and New Zealand Guideline for Mild to Moderate Head Injuries in Children was officially launched on 3rd February 2021. The electronic version of the guidelines is now on the PREDICT website under the guidelines tab and a summary of the guideline recommendations and methods used will also be published in the journal Emergency Medicine Australasia.

The guidelines, are the product of a collaboration between emergency medicine physicians, GPs, neurosurgeons, radiologists, paramedics and nurses in Australia and New Zealand, and are the first nationally consistent protocols for treating children with head injuries.  

As some of you may know we had quite a bit of media here in Australia including multiple TV, radio and print.  Selected links below:

Don’t Forget the Bubbles

GP News – the official RACGP news

The Age

The JJ Report (US)

MCRI Bulletin

Congratulations to the large team who have been involved in this comprehensive piece of work.  With special thanks to Dr Emma Tavender, Knowledge Translation Co-ordinator for PREDICT, who was the driver of the process from conception to completion.