PEAChY – O: Pharmacological Emergency management of Agitation in Children and Young people – A randomised controlled trial of Oral medication
Co-ordinating PI: Elyssia Bourke
Study Co-ordinator: Kate Klein
Study design:
Randomised, controlled, open-label, multi-centre, phase III superiority effectiveness trial of: ORAL olanzapine vs ORAL diazepam.
For further background information see: https://www.predict.org.au/projects/peachy-o-and-peachy-m-studies/
Current status:
- Study target sample size of 348 participants currently at 94% (N = 325 recruited). Nearing completion, over 12 months ahead of schedule!
- PEAChY-O is on track to be complete by mid-September 2023.
- Data cleaning is set to be finalised at all participating sites by late October, ready for final analysis.
- An abstract is planned for presentation at the PAS in January 2024.
PEAChY- M: Pharmacological Emergency management of Agitation in Children and Young people – A randomised controlled trial of IntraMuscular medication
Study design:
Randomised, controlled, open-label, multi-centre, phase III superiority effectiveness trial of: INTRAMUSCULAR olanzapine vs INTRAMUSCULAR droperidol.
For further background information see: https://www.predict.org.au/projects/peachy-o-and-peachy-m-studies/
Current status:
- Currently, 36% of the total number of participants required to meet the target sample size of 348 have been recruited.
- Low recruitment across all sites due to several reasons. For example, management of ASBD events in the ED environment can be challenging and, commonly, many enrolled participants subsequently de-escalate (in behaviour) and no longer require IM medication (i.e. they either accept oral medication or no longer require any medication).
- Education of clinical staff related to PEAChY-M continues at all sites to improve recruitment rates.