Project Snapshot – KIDS THRIVE

Trans-nasal Humidified Rapid-Insufflation Ventilatory Exchange in Children Requiring Emergent Intubation


The aim of this study is to assess the effect of THRIVE as a method for prolonging apnoeic oxygenation during the emergency intubation of children to reduce the proportion adverse events (specifically, oxygen desaturation) and increase the proportion of first attempt success for endotracheal intubation.


Study commenced 09/05/2018

  • Sample size: 960
  • Current Overall Enrolment Total: 820

Sites currently recruiting as @ 24/2/22

  • Queensland Children’s Hospital – ED & PICU
  • Children’s Hospital at Westmead – PICU
  • Gold Coast University Hospital – ED & PICU
  • Monash Children’s Hospital – ED & PICU
  • Perth Children’s Hospital – PICU
  • Royal Children’s Hospital, Melbourne – PICU & NICU
  • Townsville Hospital – ED & PICU
  • Women’s and Children’s Hospital PICU
  • University Children’s Hospital Zurich – PICU

Planned to start recruitment in 2022

  • BC Children’s Hospital Vancouver – PICU

2,191 children have been screen for inclusion into the KIDS THRIVE study and to date 820 have been randomised and consented. Of the enrolled children approximately 11% have been intubated in the ED, 80% in the PICU and 9% in the NICU. This study has been approved for consent to continue (delayed consent) due to the emergent nature of intubations. The Kids THRIVE Trial Steering Committee (TSC) have had complex ongoing discussions regarding the COVID-19 pandemic and the disease in children; and recommended the study not be paused and that sites be allowed to develop their own local plan on how to manage the recruitment of patients. In 2020 a systematic, prioritized, risk-based approach to monitoring the KIDS THRIVE project was undertaken and centralised in depth source documentation verification and monitoring of the trial is well underway. Our most exciting news is that The Kinderspital Children’s Hospital in Zurich recruited their first patient on valentine’s day this year and we welcome them to the study team. We anticipate finishing recruitment at the end of the year.

The KIDS THRIVE study gratefully received initial seed funding from the Emergency Medicine Foundation, and additional funding from the Thrasher Research Fund and the National Health and Medical Research Council.