Convulsive Status Epilepticus Paediatric Trial (CONSEPT)
This study aims to determine whether intravenous (IV) levetiracetam or IV phenytoin is the better second line treatment for the emergency management of convulsive status epilepticus (CSE) in children. We hypothesise that children treated with IV levetiracetam for CSE will do better than children treated with IV phenytoin in terms of time to clinical cessation of seizure activity, need for intubation for ongoing seizure management, need for intensive care unit (ICU) admission, serious adverse events, length of hospital stay, health care costs, and long term outcome. This research will be the first randomised controlled trial of second line anticonvulsant medication for paediatric CSE thus strengthening the evidence-based approach to the management of this life-threatening condition.
Randomised controlled trial
2013 – 2017
- The Health Research Council in New Zealand
- A+ Trust, Auckland District Health Board, Auckland, New Zealand
- Emergency Medicine Foundation
- Princess Margaret Hospital Foundation
- Eric Ormond Baker Charitable Fund
- Starship Children’s Hospital, Auckland, New Zealand
- Kidz First Hospital, Auckland, New Zealand
- Royal Children’s Hospital, Melbourne, Australia
- Princess Margaret Hospital, Perth, Australia.
- Monash Childrens Hospital, Victoria, Australia.
- Townsville Hospital, Townsville, Queensland, Australia.
- Royal Children’s Hospital, Brisbane, Australia.
- Mater Children’s Hospital, Brisbane, Australia.
- Gold Coast Hospital, Southport, Queensland, Australia.
- Sydney Children’s Hospital, Randwick, Sydney, Australia.
- Children’s Hospital at Westmead, Sydney, Australia.
- John Hunter Hospital, Newcastle, Australia.
- Women’s and Children’s Hospital, Adelaide, Australia.
200 children aged 3 months – 16 years, presenting with CSE
Clinical trial registrations