Knowledge Translation in Australasian Paediatric Acute Care Settings: a multi-centred, cluster-randomised controlled trial comparing a tailored, theory informed Knowledge Translation intervention versus passive dissemination of a bronchiolitis guideline. 

Prior research conducted by the PREDICT network has identified that there is substantial variation in practice patterns in Australasia in relation to the management of bronchiolitis, despite treatment being well defined.  In order to improve emergency department practice, the PREDICT network wish to develop Australasian wide guidelines for the management of bronchiolitis and test how this is translated into practice. Once the guideline is developed a cluster randomised controlled trial of three knowledge translation (KT) implementation strategies for the bronchiolitis guideline will be undertaken.  There are a number of ongoing trials assessing the effectiveness of various strategies for KT in emergency medicine and Paediatric Emergency Medicine, however, different environments and countries have unique structure and inherent barriers to implementing practice change, thus KT strategies used in one country should be reassessed before implementation in another to ensure optimal KT practices are found for the local environment.

Study design

Cluster randomised controlled trial

Timeframe

2016 – 2018

Funding

• National Health and Medical Research Council (ID 1058560)
• Health Research Council of New Zealand

Sample

26 hospitals from within PREDICT and the wider emergency medicine community.  (Tertiary Paediatric Emergency Departments (EDs) and  large non-tertiary mixed EDs; small/medium non-tertiary mixed EDs; 6 hospitals in New Zealand and 12 hospitals in Australia)

Clinical trials registrations

Click here

Contact

SDalziel@adhb.govt.nz

Publications to date

O’Brien SL, Haskell L, Tavender EJ, Wilson S, Borland ML, Oakley E, Dalziel SR, Gill FJ. Factors influencing health professionals’ use of high-flow nasal cannula therapy for infants with bronchiolitis – A qualitative study. Front Pediatr. 2023 Mar 16;11:1098577. doi: 10.3389/fped.2023.1098577. PMID: 37009298; PMCID: PMC10060553. [Link].

Dalziel SR, Haskell L, O’Brien S, Borland ML, Plint AC, Babl FE, Oakley E. Bronchiolitis. Lancet. 2022 Jul 30;400(10349):392-406. doi: 10.1016/S0140-6736(22)01016-9. Epub 2022 Jul 1. PMID: 35785792. [Link]

Haskell L, Tavender EJ, O’Brien S, Wilson CL, Babl FE, Borland ML, Schembri R, Orsini F, Cotterell E, Sheridan N, Oakley E, Dalziel SR; Paediatric Research in Emergency Departments International Collaborative (PREDICT) network, Australasia. Process evaluation of a cluster randomised controlled trial to improve bronchiolitis management – a PREDICT mixed-methods study. BMC Health Serv Res. 2021 Nov 29;21(1):1282. doi: 10.1186/s12913-021-07279-2. PMID: 34844605; PMCID: PMC8628472. [Link]

Haskell L, Tavender EJ, Wilson CL, O’Brien S, Babl FE, Borland ML, Cotterell E, Schembri R, Orsini F, Sheridan N, Johnson DW, Oakley E, Dalziel SR; PREDICT Network. Effectiveness of Targeted Interventions on Treatment of Infants With Bronchiolitis: A Randomized Clinical Trial. JAMA Pediatr. 2021 Aug 1;175(8):797-806. doi: 10.1001/jamapediatrics.2021.0295. PMID: 33843971; PMCID: PMC8042564. [Link]

Haskell L, Tavender EJ, Wilson CL, O’Brien S, Babl FE, Borland ML, Cotterell E, Sheridan N, Oakley E, Dalziel SR; Paediatric Research in Emergency Departments International Collaborative (PREDICT) network, Australasia. Development of targeted, theory-informed interventions to improve bronchiolitis management. BMC Health Serv Res. 2021 Aug 3;21(1):769. doi: 10.1186/s12913-021-06724-6. PMID: 34344383; PMCID: PMC8335893. [Link]

Haskell L, Tavender EJ, Wilson C, Babl FE, Oakley E, Sheridan N, Dalziel SR; PREDICT network, Australia. Understanding factors that contribute to variations in bronchiolitis management in acute care settings: a qualitative study in Australia    and New Zealand using the Theoretical Domains Framework. BMC Pediatr. 2020 May 1;20(1):189. doi: 10.1186/s12887-020-02092-y. PMID: 32357866. [Link]

O’Brien S, Craig S, Babl FE, Borland ML, Oakley E, Dalziel SR on behalf of the PREDICT Network, Australasia, ‘Rational use of high-flow therapy in infants with bronchiolitis. What do the latest trials tell us?’ A Paediatric Research in Emergency Departments International Collaborative perspective, J Paediatr Child Health, 2019 Jul;55 (7) 746–752. doi:10.1111/jpc.14496. [link].

Jamal A, Finkelstein Y, Kuppermann N, Freedman SB, Florin TA, Babl FE, Dalziel SR, Zemek R, Plint AC, Steele DW, Schnadower D, Johnson DW, Stephens D, Kharbanda A, Roland D, Lyttle MD, Macias CG, Fernandes RM, Benito J, Schuh S; Pediatric Emergency Research Networks. Pharmacotherapy in bronchiolitis at discharge from emergency departments within the Pediatric Emergency Research Networks: a retrospective analysis. Lancet Child Adolesc Health. 2019 Aug;3(8):539-547. doi: 10.1016/S2352-4642(19)30193-2. Epub 2019 Jun 7. [link]

Haskell L, Tavender EJ, Wilson C, O’Brien S, Babl FE, Borland ML, Cotterell L, Schuster T, Orsini F, Sheridan N, Johnson D, Oakley E, Dalziel SR; PREDICT. Implementing evidence-based practices in the care of infants with bronchiolitis in Australasian acute care settings: study protocol for a cluster randomised controlled study. BMC Pediatr. 2018 Jul 6;18(1):218. doi: 10.1186/s12887-018-1187-7. PMID: 29980177; PMCID: PMC6035428. [Link]

Babl F. E., Sheriff N., Neutze J., Borland M., and Oakley E., ‘Bronchiolitis Management in Pediatric Emergency Departments in Australia and New Zealand: A Predict Study’, Pediatr Emerg Care, (2008) 24 (10), 656-8. link