Project Snapshot – PARIS II

Acute Hypoxaemic Respiratory Failure aged 1-4  (Paediatric Acute Respiratory Intervention Studies)

Recruitment stats:

Study commenced December 15th 2017 and study completed recruitment 27 March 2020 with recruitment of 1512 patients.

  • Currently cleaning the dataset for analysis in August
  • Manuscript currently drafted and ready to input the results and then circulate to PARIS investigators for feedback/comment prior to publication.

14 centres participating including:


  • GCUH, Southport, Qld
  • PCH, WA
  • QCH, Brisbane, Qld
  • RCH, Melbourne, Victoria
  • Monash Health, Victoria
  • JHCH, Newcastle, NSW
  • Townsville, Qld
  • The Prince Charles Hospital, Qld
  • Caboolture Hospital, Qld
  • Ipswich Hospital, Qld
  • Redcliffe Hospital, Qld

New Zealand

  • KidzFirst, Middlemore, New Zealand
  • Starship Children’s Hospital, New Zealand
  • Waikato Hospital, New Zealand

No significant issues with processes, eCRF, or site recruitment during the course of the study.  Data cleaning has taken a longer period of time due to occurring virtually for a large dataset.


Extension of the PARIS Trials has now evolved into a new PARIS trial named Remote PARIS.  This will commence in August 2021 and is set in three remote and rural centres in Far North Qld: Cooktown, Weipa and Thursday Island.  The aim of this study is implementing what we have already learned with PARIS 1 and PARIS 2 pilot with the hypothesis that there will be reduced transfer rates out of these hospitals to Cairns and Townsville.  Education has already commenced, and the study starts in the next few weeks with the new Remote Context Nasal High Flow in children Qld Guideline being approved.

Donna Franklin is working with Weipa nurse and PhD candidate Sally West (James Cook University) on this study.  The PARIS study has grown many legs and we hope that the Remote PARIS study will be as successful as the other PARIS studies.